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Apple Polyphenol (Procyanidin
B2 and C1)
Phytochemical concentrate found in the skin
of unripe apples that acts as potent antioxidant. It protects cells
against free radicals, reactive atoms that contribute to tissue damage in
the body. These chemical compounds are being studied extensively in labs
around the world for their health effects in major diseases including
treatment of hair growth. Studies showed that after sequential use, an
increase of almost 80% of hair diameter and an increase of number of total
hairs was shown, with no side effects.
In 2000, Japanese researchers presented
their findings to the international community on the hair growing effects
of apple polyphenols- specifically one known as procyanidin B-2. They
identified two successful compounds- one from chardonnay grapes, and one
extracted from unripe apples. Here is what the cell culture tests
The procyanidin B-2 fraction clearly
outperformed the grape extract, and nearly doubled the hair growth
activity of minoxidil. "Procyanidin B-2 purified from apples,"
stated the research team, "shows the highest activity of more than
300% relative to controls."
In the same year, in a double-blind
placebo-controlled trial, nineteen men with male pattern baldness were
studied with a daily topical application of a 1% procyanidin B-2 solution,
extracted from apples. Ten other balding men served as controls, receiving
a placebo solution. After 6 months, the study concluded:
The increase in the number of total
hairs and terminal hairs in the procyanidin B-2 group subjects was
significantly greater than controls
78.9% of subjects showed an increased
mean value of hair diameter
"Procyanidin B-2 therapy shows
promise as a cure for male pattern baldness."
Following the revelations, an attempt was
made to further understand the mechanism by which the remarkable hair
growth effects occurred. The results were published in the prestigious
British Journal of Dermatology: Procyanidin B-2, extracted from apples,
promotes hair growth: a laboratory study, Br J Dermatol. 2002
In this study, the researchers concluded
that procyanidin B-2 acts to diminish protein kinase C isozymes, which
play an important role in the hair growth cycle. Procyanidin B-2 seems to
promote hair growth by down regulating PKC in both the anagen (active
growth phase) and telogen (resting phase) of the hair follicle. When the
anagen phase is prolonged, and the telogen phase is shortened, increased
hair growth results.
Two more clinical trials and a total of
seven published studies have now confirmed the surprising hair
growth-promoting effects of apple procyanidins. Here is a summary of those
Total Number of Hairs: Significantly
Total Number of Terminal Hairs:
Increase in Hair Diameter: 78.9%
Ratio of Thicker (terminal) Hairs:
Compared to Minoxidil: Up to 200% Better
Hair Follicle Activation: Intensive
In the most exciting development yet,
Japanese researchers released a new study late in 2005. Once again,
procyanidin therapy was proven successful in re-growing hair in subjects
with male pattern baldness. The new study, published in the Journal of
Cosmetic Dermatology, confirmed the findings of earlier studies, showing
clear improvement in the number of hairs and the density of hairs in the
Building on the success of earlier trials,
the study was extended to 12 months in the procyanidin group, and proved
that longer term procyanidin therapy was even more successful than prior 4
and 6 month trials.
Copper Peptides have two main properties: (1)
potent tissue protective anti-inflammatory agents that limit oxidative
damage after tissue injury, and (2) tissue remodeling activation agents,
that is, the processes for removal of damaged protein and scar tissue and
their replacement by normal tissue. Studies at numerous universities and
research institutes have found copper-peptides to improve hair transplant
success, increase hair follicle size, stimulate hair growth and reduce hair
Research scientists at the University of San
Francisco Wound Center may have stumbled onto the answer to hair loss:
something that has frustrated mankind for centuries. Their discovery was
made while applying a synthetically formulated compound, Copper Peptide, to
severe wound areas on several patients. During this process something
unusual happened. Not only did the wounds heal about 30 percent faster, but
a significant stimulation of the follicular cells occurred. As a side
effect, these tripeptide complexes actually grew hair around the wound area.
The discovery was so startling that they then
applied the same Copper Peptide complex to a female patient who had suffered
roughly 90 percent alopecia (hair loss) for years. After about six months of
use, she had recovered almost 100 percent of her hair. Dr. Loren Pickart,
the leading authority in Copper Peptide technology, describes it as being
like a protein injection to the scalp.
Tests were then conducted with chemotherapy
patients and recent hair transplant recipients, all with great success in
stimulating newer and stronger hair follicles. The implications of such a
startling discovery have gotten the attention of several large companies.
Several compounds have recently gained
recognition for ameliorating cellular dysfunction. One type of dysfunction
which has been well studied is alopecia for which anti-alopecia agents such
as minoxidil and cyoctol have gained attention. However, most of these
anti-alopecia agents are only minimally effective in some cases and/or can
cause adverse dermatological or systemic reactions.
A method for ameliorating a cellular
dysfunction of a tissue, which is also useful as the treatment of hair loss
and stimulation of hair growth comprises of administering a nitroso or
nitrone spin trap to the affected tissue. These agents inhibit the reaction
of superoxide and nitric oxide to produce peroxinitrite. Spin traps can
provide unique protection against free radicals.
Scientists discovered that nitrone and
nitroso spin traps have properties in the body for ameliorating cellular
dysfunction in tissue attributed, in part, to high energy oxygen and
hydroxyl free radicals, and enhancing recuperation of the tissue.
N-t-butyl-.alpha.-phenylnitrone (PBN) can be administered, for example, as
an anti-alopecia agent to stimulate hair growth.
Spin traps can be administered to the skin to
be treated, including the scalp. Depending on the type of hair loss or
alopecia being treated and the conditions thereof, the stimulation of hair
growth can usually be obtained by topical application, preferably repeated
daily application for a period of 3-6 months. The utility of topically
applied spin traps also includes an increased rate of growth, increased hair
diameter, follicular neogenesis, and the like; inhibiting hair loss or
alopecia from progressing, for example, in male pattern baldness, or during
the course of treatment with other therapeutic agents known to induce hair
loss, such as chemotherapy or radiation therapy in cancer treatment.
Spin traps can be used alone or in
combination with other compounds which are available to enhance the function
of hair growth stimulation.
If we first examine the role of androgens,
specifically dihydrotestosterone (DHT), we find that this hormone has been
thought to slowly "choke" the growth of the hair follicle by
inhibiting the function of an enzyme in the hair follicle called adenylate
cyclase. Suffice it to say that when DHT concentrations remain high in the
scalp, we see terminal (thick, coarse) scalp hair become reduced to vellus
hair (fine, thin peach fuzz).
Ketokonazole is an antifungal medication and
is significant for those combating hair loss for a couple of reasons. First,
ketoconazole's action as an antifungal agent reduces scalp irritation caused
by fungal colonization or infection. The reduction of the inflammatory
process that occurs in male pattern alopecia is crucial. Second,
ketoconazole has been shown in many studies to physiologically have an
anti-androgenic (anti-DHT) effect.
On March 04, 2001, at the American Academy of
Dermatology Meeting in Washington DC, scientists presented the findings of a
study done on 1% ketoconazole shampoo which has good news for hair loss
sufferers. It has long been known that 2% prescription ketoconazole has
beneficial effects on Androgenic Alopecia (MPB). It however has been unclear
whether the same benefits can be obtained by using the non-prescription 1%
In the study presented, one hundred male
volunteers with mild to moderate dandruff and somewhat oily scalp, were
using, in a double-blind fashion, either a 1% ketoconazole shampoo or a 1%
zinc pyrithione shampoo, 2-3 times a week for 6 months.
Analysis of the different parameters set up
in the study shows that the hair diameter gradually increased with
ketoconazole use (+8.46%) over a 6 month period, whereas the diameter showed
a trend to decrease with zinc pyrithione use over the same period (-2.28%).
The sebum excretion rate was reduced with ketoconazole (-6.54%) while it
increased with zinc pyrithione (+8.2%) over the same period of time. The
number of hair shed over a 24-hour period was reduced by 16.46% with
ketoconazole and 6.02% with zinc pyrithione after 6 months. Finally, the
percentage of hairs in anagen phase increased by 6.4% during the study time.
The results are similar to a previous study
done on 2% prescription strength Ketokonazole where it was shown that use of
2% ketoconazol yielded a 7% average increase in hair shaft diameter similar
to what was achieved by the control group using 2% Minoxidil and a
This research clearly indicates that using 1%
or 2% ketoconazole 2-3 times per week, will have positive effects on hair
growth as well as controlling dandruff.
Rooibos or Red Bush Tea - a hardy shrub
indigenous to the North Western Cape of South Africa – is an exciting new
botanical ingredient with potent antioxidant and anti-inflammatory
properties, well documented in the literature. Clinically Rooibos is often
prescribed for nervous tension, allergies, stomach and digestive problems.
However, the results from an independent study also showed a significant
improvement in hair growth.
Studies were initiated at an independent
laboratory (Dermascan, France) to study the effect of the use of Rooibos in
a hair lotion on a group of healthy persons who were suffering from the
problem of hair loss. A 90 day trial was conducted comparing a hair lotion
containing 10% Rooibos with a placebo lotion. 5 ml of the alcoholic
solutions were applied daily.
After 90 days results showed a significant
increase of the hair growth speed in the lotion containing Rooibos compared
with the placebo. An increase in the hair growth speed was observed with 89%
of the volunteers with no undesirable reactions (irritation or allergy).
The participants were next asked to fill in a
questionnaire. When the results were tallied, 67 percent rated their hair
loss as zero or low, 78 percent saw a low to medium improvement, 45 percent
saw a low to medium re-growth of hair, and 63 percent considered their hair
had become smoother and more shiny. Conclusion: results show that most of
the volunteers had a remarkable improvement in both the increase of the
speed of hair growth, the decrease in hair loss and an overall improvement
in hair condition.
Sulphur is present in protein-rich foods
containing high levels of the amino acids methionine and cysteine. These
foods include meat, fish, legumes, nuts, eggs, and vegetables, especially
onions. However, sulphur has recently become a popular nutritional
supplement and topical treatment, thanks to the discovery of
methylsulfonylmethane, or MSM.
The use of MSM as a nutritional supplement
and topical application is relatively recent. An American chemist named
Robert Herschler, began studying MSM in 1955. However, another man, Dr.
Stanley Jacob with Oregon Health Sciences University in Portland, is
considered by many to be the father of MSM. Dr. Jacob found that simple
marine life like algae and plankton convert inorganic sulphur to organic
sulphur compounds. These compounds are known as dimethylsulfonium salts.
These salts are transformed into dimethyl sulfide (DMS), which is released
into the atmosphere and is converted by ultraviolet light into dimethyl
sulfoxide (DMSO). When DMSO oxidizes, it turns into MSM and is absorbed by
plants that become food for animals and humans. MSM is a white, crystalline
powder that is odorless and nearly tasteless. When taken as a dietary
supplement, MSM proved to have the same health benefits as DMSO without
side-effects such as bad breath, itchy skin, nasal congestion, and shortness
Why does MSM help with the development of
longer and stronger hair? Various scientific studies have proven that MSM
contributes a definite normalizing effect on body functions. The sulfur
normally provided to the body by MSM is required for healthy collagen and
keratin which are essential for healthy hair, skin and nails. MSM also has
proven antioxidant benefits which can disrupt or alter damaging chain
reactions of lipid peroxidation in the cell membranes.
MSM has been widely used as a dietary
supplement without any reports of allergy or intolerance related to its use.
Supplements of MSM are comfortably assimilated without side effects. There
are no known contraindications. The sulfur normally provided to the body by
MSM is required for healthy collagen and keratin which are essential for
healthy hair, skin and nails. Healthy hair is stronger hair and hair that
can achieve its natural genetic growth patterns.
Revita® provides MSM to your scalp and hair,
acting on hair loss through multiple compounds and mechanisms, from
prevention to later phases.
Active caffeine ingredient helps to regulate
the effects of testosterone levels. Male pattern baldness is known to occur
in individuals with a sensitivity to testosterone, causing damage to hair
follicles that eventually leads to baldness. Studies have shown that after
caffeine treatment average hair growth was increased by around 46% and the
life cycle of the hair was extended by 37%.
Caffeine is a xanthine alkaloid compound that acts as a stimulant in humans.
Caffeine is a central nervous system (CNS) stimulant, having the effect of
warding off drowsiness and restoring alertness.
The independent study at the University of
Jena used hair samples from the scalps of young men entering into the first
stages of hormone-related hair loss. The study relied on a hair organ
culture that used four different types of testing samples. The first was a
nutrient-based sample, the second a testosterone only sample, the third was
a caffeine only sample and the fourth a mixture of caffeine and
According to the research, results showed
that the samples containing the caffeine nutrient helped to stave off hair
loss and encouraged new hair growth, while the sample that relied on
testosterone only led to increased hair loss.
New studies by the Berlin-based "Charité"
university clinic prove the absorption of caffeine by the hair follicles
after being left on for a mere 2 minutes. They also show that the caffeine
remains detectable up to 24 hours.
L-Carnitine, a vitamin-like nutrient, occurs
naturally in the human body and is essential for turning fat into energy.
Active energy metabolism is an essential prerequisite for the growth of
strong and healthy hair. In biological systems ATP acts as the universal
energy currency. One of the most potent bio-actives that significantly
increases cellular ATP contents is carnitine tartrate.
Statistical evaluation demonstrated a
significant increase in ATP equivalents in human hair roots treated with
carnitine tartrate, showing that carnitine tartrate is an ideal ingredient
for hair care formulations, providing energy for the optimal environment to
produce strong and healthy hair.
Throughout the test period ATP content within
plucked hair follicles was determined twice daily using a commercially
available test kit. Statistical evaluation of baseline adjusted values
demonstrated a significant increase in ATP equivalents in human hair roots
treated with carnitine tartrate. These effects were absent in the placebo
group, thus underlining the stimulating activity of carnitine tartrate.
The outstanding bio-activity of carnitine
tartrate was furthermore demonstrated in a second study, assessing the
effects after a single application of a shampoo formulation supplemented
with carnitine tartrate. Again, ATP levels in plucked human hair follicles
were significantly increased. They conclude that carnitine tartrate is an
ideal ingredient for hair care formulations, providing energy for the
optimal environment to produce strong and healthy hair.
Revita® contains Carnitine Tartrate in its
formulation, in order to fulfill the energy needs of your scalp and hair,
acting on hair loss from prevention to later phases
Amino acids are the building blocks of
protein, from which hair is created. They are assembled in the correct
sequence by stem cells to form keratin, a complex and immensely strong hair
protein. Vital amino acids have to be replaced consistently, as damage is
accumulated over time. We can replace a combination of these lost amino
acids directly into the hair, where they are shown to provide significant
tensile benefits to the hair shaft.
Hair is composed primarily of proteins (88%).
These proteins are of a hard fibrous type known as keratin. Keratin protein
is comprised of what we call "polypeptide chains.” The word,
polypeptide, comes from the Greek word "poly" meaning many and
"peptos" meaning digested or broken down. In essence, if we break
down protein, we have individual amino acids.
Many (poly) amino acids joined together form
a "polypeptide chain". Two amino acids are joined together by a
"peptide bond", and the correct number of amino acids placed in
their correct order will form a specific protein; i.e. keratin, insulin,
collagen and so on. The "alpha helix" is the descriptive term
given to the polypeptide chain that forms the keratin protein found in human
hair. Its structure is a coiled coil. The amino acids link together to form
the coil and there are approximately 3.6 amino acids per turn of the helix
(coil). Each amino acid is connected together by a "peptide bond".
The peptide bond is located between the carbon atom of one amino acid
extending to bond with the nitrogen atom of the next amino acid.
L-Arginine is a semi-essential amino acid
synthesized by the body from L-Ornithine. Arginine + Ornithine support
protein synthesis because they are involved in the transport and storage of
The usage of taurine corrects what is known
as the "rigidification" of the connective sheath that surrounds
the Pilosebaceous unit and hair follicles, specifically those affected by
pattern hair loss. This is a novel and previously undisclosed angle on hair
loss treatment that has yet to be touched upon in any of the medical
literature or prior publications.
The amino acid, l-cysteine speeds up hair
growth and increases hair shaft diameter resulting in fuller hair.
L-cysteine has been reported to facilitate longer hair growth, beyond what
is genetically programmed. L-cysteine also provides potent antioxidant
protection to the hair follicle. Users of topical n-acetyl-cysteine have
reported hair regrowth.
Revita® provides amino acids directly into
the hair follicle, where they are shown to provide significant tensile
benefits to the hair shaft.
The emu, Dromaius nova hollandiae, is a
flightless bird part of a group called ratites which also includes the
ostrich and the kiwi. Modern Australians learned early on from the
Aborigines the many valuable qualities in the emu and its oil. The earliest
research studies in emu oil come from Australia, and Australia continues to
export emu oil to this day.
In the United States today there is a growing
network of research labs interested in emus and their incredible oil. Emu
oil is rendered from a thick pad of fat on the back of the bird that was
apparently provided by nature to protect the animal from the extreme
temperatures in its Australian homeland.
Emu oil is an oil that is deep penetrating and super hydrating to hair and
skin - an all-natural tissue nutrient. Michael Hollick, MD, Ph.D., Professor
of Medicine, Physiology, and Dermatology at Boston University School of
Medicine conducted a study involving emu oil and hair growth. His study
found that there was a 20% increase in growth activity of skin that received
emu oil, compared to skin that received corn oil. Looking at the hair
follicles, Dr. Hollick realized they were much more robust, the skin
thickness was remarkably increased, suggesting that emu oil stimulated skin
growth and hair growth. Additionally, the study showed that over 80% of hair
follicles that had been "asleep" were woken up, and began growing.
Emu oil is anti-inflammatory, which may be in
part why it stimulates hair growth. Emu Oil has also been shown to be a 5
alpha reductase inhibitor in target tissues when topically applied, which
likely contributes significantly to its hair growth properties. A third
important property of emu oil is that it is bacteriostatic.
Emu Oil contains a multitude of Essential
Fatty Acids (EFA) which help to "feed" the skin. Consumers who
suffer from natural forms of baldness have reported hair re-growth. The good
news in these reports is that Emu Oil helps stimulate and awaken the
sleeping hair follicle.
Biotin is a member of the B-vitamin family
and a major component in the natural hair manufacturing process -- it is
essential to not only grow new hair, but it also plays a major role in the
overall health of skin and nails. The beneficial effects of biotin on hair
may be linked to its ability to improve the metabolism of scalp oils. The
biotin when absorbed by the scalp may promote hair growth. and it is able to
penetrate the hair shaft making it expand which actually thickens the hair
Biotin is used in cell growth, the production
of fatty acids, metabolism of fats and amino acids. It plays a role in the
Krebs Cycle, which is the process in which energy is released from food.
Biotin is often recommended for strengthening hair and nails. Biotin is so
important to hair health, that many dermatologists prescribe biotin
supplements to their patients as part of their medical treatment for hair
Revita contains Biotin, a major component in
the natural hair manufacturing process.
statements have not been evaluated by the food and drug administration.
The products mentioned are not intended to diagnose, treat, cure or
prevent any disease. Always see your licensed health care professional for
proper diagnosis and treatment.
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