Below are excerpts from the book "All About
DIM"written by Michael A.
Zeligs, MD, and A. Scott Connelly, MD and published by Avery, a member of
Penguin Putnam Inc. The book can be ordered from this site if you'd like
even more information on the benefits of DIM.
Overview of DIM
healthy effects of eating vegetables have been known for many years. It is only
recently, however, that scientists have started to figure out exactly which
substances in these foods provide the benefits. DIM is one of these substances.
exactly is DIM?
Diindolylmethane, or DIM for short, is a plant indole -- a plant compound with
health-promoting properties. DIM and other plant indoles are found in all
cruciferous vegetables. Cruciferous vegetables include cabbage, broccoli,
Brussels sprouts, and cauliflower. These plants have cultivated for centuries
and were initially used for medicines.
twenty years ago, scientists discovered that when broccoli was added to the
diets of study animals, it could prevent certain forms of cancer. In more
recent scientific studies, this same cancer protection was shown to result from
simply adding supplemental DIM Diindolylmethane or related plant indoles to the
animals' diets in place of the broccoli. Recently, regular use of supplementary
DIM and its indole relatives has shown that many of these health-promoting
effects arise from a beneficial shift in the balance of the sex hormones,
estrogen and testosterone.
chew raw or lightly cooked cruciferous vegetables, plant enzymes -- substances
that start a reaction -- are activated, which allows DIM Diindolylmethane to
enter your body. But to get the most benefit from this indole, you would need
to consume very large quantities of raw vegetables each day. To overcome this
problem, absorbable forms of pure DIM (such as BioResponse DIM) have been
developed as dietary supplements that use special absorption-enhancing
stimulates more efficient estrogen metabolism. Supplementing the diet with DIM
Diindolylmethaneand eating cruciferous vegetables increases the specific
aerobic metabolism for estrogen, multiplying the chance for estrogen to be
broken down into its beneficial, or "good" estrogen metabolites.
These "good" estrogen metabolites are known as the 2-hydroxy estrogens.
Many of the benefits that are attributed to estrogen, which include its ability
to protect the heart and brain with its antioxidant activity, are now known to
come from these "good" metabolites.
Diindolylmethane increases the "good" estrogen metabolites, there is
a simultaneous reduction in the levels of undesirable or "bad"
estrogen metabolites. These include the 16-hydroxy estrogens, which are not
antioxidants and can actually cause cancer. Greater production of these
"bad" estrogen metabolites is promoted by obesity and exposure to a
number of manmade environmental chemicals. These "bad" estrogen
metabolites are responsible for many of estrogen's undesirable actions in women
and men, including further unwanted weight gain, breast cancer, and uterine
addition, a slow metabolism of estrogen, which leaves too much unmetabolized
active estrogen known as estradiol in the body, can be a problem for both women
and men. Elevated estradiol causes moodiness and breast pain in women and loss
of sex drive in men. By promoting a healthy estrogen metabolism, DIM
Diindolylmethane adjusts the balance of estradiol to its "good"
metabolites. This also can result in a more desirable action from testosterone.
Testosterone supports energy and mood and helps sustain interest in sex in both
men and women. When supplemental DIM is taken along with a program of regular
exercise, it can help estrogen and testosterone contribute to good physical
These statements have not been evaluated by the food and drug
administration. The products mentioned are not intended to diagnose, treat,
cure or prevent any disease. Always see your licensed health care professional
for proper diagnosis and treatment. These results are atypical your results may