Reduce Body Fat with Conjugated Linoleic Acid
CLA and Weight Loss Dietary CLA has been shown to effect body composition by creating a
reduction in body fat and an enhancement of lean tissue or muscle.
According to Michael Pariza at the University of Wisconsin, this area of
CLA research is the most supported.
Recently, the research has focused on
clinical studies with much success; showing statistically significant
reduction in body fat as measured by BMI (Body Mass Index). The studies
showed a significant decrease measured in waistline inches, a positive
result for weight loss in mildly overweight subjects and an increase in
strength. Human clinical studies to substantiate improved body composition
have been conducted worldwide. Positive results of CLA supplementation
have been seen at research centers worldwide including:
Kent State University, University of Memphis,
University of Wisconsin, USDA Western Human Research Center, Medstat
Research Ltd. in Norway, Uppsala University in Sweden, University of
Kumanoto in Japan and University of Tours in France.
CLA appears to exert direct effects on
adipocytes, which are the principle sites of fat storage and skeletal
muscle cells and are the primary sites of fat combustion. It has been
proposed that the physiologic mechanism of body fat reduction by CLA
involves inhibition of fat storage in adipocytes coupled with elevated
b-oxidation in skeletal muscle. An overall increase in skeletal muscle
tissue may be mediated at least in part via the inhibition of
CLA is a metabolically active compound that
has been demonstrated to dramatically reduce body fat and increase lean
body tissue. The mechanisms of action are not completely understood, but
because CLA has been shown to affect a wide variety of enzymes and
hormones in the body, multiple mechanisms may come into play.
Numerous human studies are in progress,
which will make a stronger case for efficacy and dose response.
Expectations are high that research will additionally show no regain of
body fat lost, suggesting that Tonalin™ CLA should be included with
every diet regimen.
CLA and Cancer In the early 1980s, a noted doctor, Michael Pariza, working at the
University of Wisconsin and his colleagues discovered that CLA interfered
with the growth of cancer tumors. Since then, a number of other studies
have further shown CLA's cancer-fighting potential.
Some of these studies have shown that CLA
can suppress cancer development in animals, and in human cancer cell lines
in vitro. Dietary CLA also seems to protect against breast cancer in
humans, as demonstrated in a large French study by Lavillonniere et. al.
at the University Francois-Rabelais.
When breast adipose tissue was collected at
the time of surgery, higher levels of CLA in the control group suggested
CLA's protective effect against breast cancer. A different study in
Finland confirmed the reverse correlation between milk fat intake, which
contains CLA and breast cancer. Over the next few years, additional
studies are planned to help further understand the role CLA may play in
the fight against cancer.
CLA and Arteriosclerosis
Over time, cholesterol and other substances can form plaque in your
arteries, narrowing them, reducing your heart's blood supply. This is
called arteriosclerosis. In a collaborative study where a diet high in
cholesterol was fed along with CLA to animals, the data suggested that CLA
could help prevent arteriosclerosis. By week 12, the LDL and total
cholesterol and triglyceride counts were markedly lower in the blood of
the animals fed CLA.
Other studies have indicated that CLA
reduces plasma lipoproteins and early aortic arteriosclerosis in the
animal model. According to Dr. David Kritchevsky at the Wistar Institute,
another significant finding is the apparent ability of CLA to reduce the
severity of pre-induced arteriosclerosis lesions in the animal model.
Overall, CLA has considerable potential for the prevention and treatment
of arteriosclerosis, and studies continue to reveal it's potential health
CLA and Diabetes
One of the most important health benefits of CLA could possibly be its
ability to affect and treat some types of diabetes. According to Dr.
Martha Belury at Purdue University and Dr. John Vandel Heuvel at Penn
State University, CLA normalizes impaired glucose tolerance in non
In earlier experiments by Houseknecht et.
al., it was observed that CLA and troglitazone reversed the symptoms of
diabetes in a specific diabetic animal model. Effects included decreased
triglycerides, insulin and leptin, and improved glucose utilization.
Belury and Vanden Heuvel conclude that CLA may represent an important
agent for the treatment of Type II diabetes.
Because CLA isomers share many of the
attributes of the clinical thiazolidinedione drug, troglitazone, without
exhibiting as many side effects, CLA may represent a new
insulin-sensitizing agent for treatment of Type II diabetes. Additional
clinical studies are scheduled at many universities worldwide in order to
further explore the possibilities of using CLA for diabetes treatment.
CLA and the Immune System
In 1991, evidence obtained through the collaborative efforts of Dr. Mark
Cook and Dr. Michael Pariza at the University of Wisconsin revealed the
immune boosting potential of CLA.
Feeding CLA to chicks provided partial
protection against the catabolic effects of exposure to endotoxin. This
research expanded to include rodents and supported the fact that CLA-fed
animals exhibit enhanced immune functions.
CLA is the only known nutrient that
enhances the immune system and protects against the harmful "cellular
backlash" that occurs when the immune system is stimulated. As
published in separate issues of Cancer Research, CLA has been shown to be
an effective antioxidant in vitro according to Dr. Yeong Ha and in vivo
according to Dr. Clement Ip.
Because numerous studies indicate that
oxidative reactions are associated with the development of cancer and arteriosclerosis, CLA's ability to reduce the harmful effects of these
oxidative reactions could be its most important health benefit In
addition, research suggests that CLA may ease the inflammation that occurs
when the immune system is challenged.
statements have not been evaluated by the food and drug administration.
The products mentioned are not intended to diagnose, treat, cure or
prevent any disease. Always see your licensed health care professional for
proper diagnosis and treatment.
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